The Role of Pten Trafficking in Normal and Abnormal Cortical Development

Grant number: 1066895 | Funding period: 2014 - 2016

Completed

Abstract

Autism is a complex neurodevelopmental disorder that is estimated to affect 1 in every 100 children. Currently we have no medical treatments to cure the disease. PTEN is a tumor suppressor that has been genetically linked to autism as it functions to inhibit cell growth that can result in abnormal brain development. In this grant we aim to study the location and function of PTEN and how failure of this system can result in neurodevelopmental diseases such as autism.

Related publications (4)

Ubiquitin Regulation of Trk Receptor Trafficking and Degradation

SS Murray, AW Wong, J Yang, Y Li, U Putz, SS Tan, J Howitt

2019-03-01

The regulation of Trk receptors is critical for orchestrating multiple signalling pathways required for developing and maintaining..

A method for isolating cortical interneurons sharing the same birthdays for gene expression studies

HX Ng, EP Lee, BL Cavanagh, JM Britto, SS Tan

2017-09-01

The two neuronal populations in the cortex, pyramidal neurons and interneurons, can be separated based on neurotransmitter identit..

Engineered Exosomes as Vehicles for Biologically Active Proteins

U Sterzenbach, U Putz, LH Low, J Silke, SS Tan, J Howitt

2017-06-07

Exosomes represent an attractive vehicle for the delivery of biomolecules. However, mechanisms for loading functional molecules in..

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

J Howitt, LH Low, U Putz, A Doan, J Lackovic, CP Goh, J Gunnersen, J Silke, SS Tan

2015-04-01

Pten controls a signaling axis that is implicated to regulate cell proliferation, growth, survival, migration, and metabolism. The..

University of Melbourne Researchers

Seong Tan